清末民初,佛山武学宗(zōng )师(shī )黄(huáng )飞(fēi )鸿(hóng )因(yīn )噩(è )梦(mèng )预感女记者莫十三遇险,携弟子前往古云村寻人。村中蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒(qín ),身(shēn )中(zhōng )噬(shì )魂(hún )蛊(gǔ )。黄(huáng )飞(fēi )鸿(hóng )闯(chuǎng )祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒,幸得卧底蜈蚣教的鬼脚七暗中相助。众人合力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后(hòu ),线(xiàn )索(suǒ )指(zhǐ )向(xiàng )广(guǎng )州(zhōu )东(dōng )瀛(yíng )会馆。黄飞鸿潜入会馆救出被掳孩童,对决主事服部一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸(huò )乱(luàn )羊(yáng )城(chéng ),以(yǐ )莫(mò )十(shí )三(sān )性(xìng )命(mìng )相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无影脚,击杀麦克罗。蛊毒尽解,百姓恢复神智,广州重归太平,宝芝林重回烟火日常。